Retin-A (tretinoin) is a prescription drug that can be used if you have been diagnosed with acne and have trouble keeping it under control without help of this kind. This medicine is supposed to be applied topically, once a day before going to bed but your health care provider may give other recommendations before prescribing this medicine. If you have a history of an allergic reaction to some medications - make sure you report this fact to your health care provider, as there is a chance the same reaction can occur when Retin-A is applied. You need to be patient when you start using this drug for the first time, as several days or even a couple of weeks may be required for you to see the first results of the treatment. You are not going to see the progress instantly, so applying Retin-A regularly and just as prescribed is the best way for you to benefit from the treatment and keep your acne under control. Never use more of Retin-A than recommended or apply it more often than prescribed, as this is not going to produce more results and can worsen some of the side effects. The following side effects are normal and will disappear soon: itching, peeling, redness, stinging, burning, and dry skin.